GeVIR Banner

Export Results to CSV Clear Search

Genes Fold Enrichment Color Codes
  • Gene Name, Canonical Transcript - gene identifiers from gnomAD database (Build 37)
  • GeVIR % - gene rank measured in percentiles based on Gene Variation Intolerance Ranking (GeVIR) (low values indicate more variation intolerant genes, which is also true for "LOEUF %" and "VIRLoF %"). GeVIR is a method which we developed and applied on a list of 19,361 genes to sort them based on number, length and evolutionary conservation of regions without functional variants (i.e. between two missense, loss-of-function, insertion or delition variants) in gnomAD database (version 2.0.1). Only canonical transcripts were analysed.
  • LOEUF % - gene rank measured in percentiles based gnomAD loss-of-function observed/expected upper bound fraction (LOEUF) (see Figure 1). For more information about this metric, please read "Constraint" section of MacArthur Lab blog post. If you use this metric please cite gnomAD flagship paper and use most up-to-date values from gnomAD website.

    LoF observed/expected (o/e) upper Confidence Interval (CI)

    Figure 1. Screenshot of ELN gene constraint metrics from gnomAD browser

  • VIRLoF % - gene rank measured in percentiles based on both GeVIR and gnomAD LOEUF (shows the best overall performance, see Figure 2). If you use this metric please cite both GeVIR and gnomAD flagship paper.
  • GeVIR AD, LOEUF AD, VIRLoF AD, GeVIR AR, LOEUF AR, VIRLoF AR - to help users interpret gene ranks, we calculated fold enrichment of Autosomal Dominant (AD) and Autosomal Recessive (AR) genes with known molecular basis of disorder in OMIM in a range of +-5% of gene X (see Figure 2). Statistical significant fold enrichements (Fisher Exact Test p-value < 1e-5) are shown in bold in the table. For example CDK19 gene's GeVIR % is 2.37, so examined range is from 0 (2.37-5, rounded to minimal percentile) to 7.37% (2.37+5). Genes in this range are ~4 times more often (4.05 fold enrichement) associated with AD diseases and ~4 times less often (0.25 fold enrichement) associated with AR diseases. Both enrichment of AD genes and deficiency of AR genes is statistical significant. Thus GeVIR metric adds supportive evidence that CDK19 is more likely to be associated with AD than AR disease.

    Gene Percentiles AD AR Fold Enrichment

    Figure 2. Fold Enrichment of known Autosomal Dominant (AD) and Autosomal Recessive (AR) genes of each gene in the ranked lists (GeVIR, LOEUF, VIRLoF. AD genes are enriched among top ranked genes (lowest percentiles), whereas AR genes are enriched among middle ranked genes (approximetly 35-65 percentiles). Combined metric (VIRLoF, purple) shows the best perfornance, i.e. high ranked genes are more often associated with AD than AR diseases, low ranked genes are less often associated with both AD and AR diseases.
Gene Name Canonical Transcript GeVIR % LOEUF % VIRLoF % GeVIR AD LOEUF AD VIRLoF AD GeVIR AR LOEUF AR VIRLoF AR
ZNF362 ENST00000539719 2.72 15.85 6.69 4.02 1.89 3.01 0.29 0.68 0.32
NHP2L1 ENST00000401959 2.72 38.77 18.76 4.02 0.70 1.57 0.29 1.66 0.82
TAF13 ENST00000338366 2.73 58.70 28.85 4.01 0.54 0.81 0.29 1.44 1.31
KCNA2 ENST00000485317 2.73 19.15 8.30 4.01 1.49 2.57 0.29 0.76 0.37
SERBP1 ENST00000370995 2.74 4.93 1.73 4.01 3.26 4.24 0.29 0.32 0.23
KPNA4 ENST00000334256 2.74 3.32 1.19 4.01 3.42 4.44 0.29 0.27 0.21
MAX ENST00000358664 2.75 22.15 10.00 4.00 1.52 2.26 0.29 0.83 0.42
RBFOX1 ENST00000311745 2.75 14.69 5.97 4.00 1.99 3.26 0.28 0.62 0.30
NAB2 ENST00000300131 2.76 22.57 10.22 4.00 1.48 2.21 0.28 0.85 0.42
H2AFY ENST00000511689 2.76 23.43 10.69 3.99 1.42 2.18 0.28 0.92 0.43
CCNK ENST00000389879 2.77 3.70 1.30 3.99 3.33 4.36 0.28 0.30 0.22
YWHAG ENST00000307630 2.77 10.96 4.15 3.99 2.10 3.78 0.28 0.52 0.23
GNB1 ENST00000378609 2.78 3.05 1.08 3.99 3.46 4.41 0.28 0.28 0.21
TMEM57 ENST00000374343 2.78 9.54 3.57 3.98 2.51 3.84 0.28 0.49 0.24
DKC1 ENST00000369550 2.79 5.07 1.80 3.98 3.21 4.23 0.28 0.33 0.23
ZNF148 ENST00000360647 2.79 1.18 0.58 3.98 4.02 4.69 0.28 0.28 0.17
MAP2K6 ENST00000590474 2.80 12.29 4.81 3.98 2.06 3.67 0.28 0.59 0.24
KCNH1 ENST00000271751 2.80 17.46 7.47 3.97 1.58 2.78 0.28 0.74 0.33
NAA50 ENST00000240922 2.81 32.03 15.19 3.97 0.92 1.83 0.28 1.48 0.64
KLF9 ENST00000377126 2.81 19.64 8.56 3.97 1.43 2.52 0.28 0.74 0.36
PRPF3 ENST00000324862 2.82 0.36 0.41 3.97 4.13 4.78 0.28 0.28 0.18
MTOR ENST00000361445 2.83 4.96 1.78 3.96 3.25 4.22 0.28 0.32 0.23
RNF7 ENST00000273480 2.83 71.56 35.41 3.96 0.53 0.87 0.28 1.07 1.76
CBLN1 ENST00000219197 2.84 59.38 29.25 3.96 0.51 0.84 0.28 1.41 1.34
PHIP ENST00000275034 2.84 1.19 0.61 3.96 4.03 4.67 0.28 0.28 0.19

Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.